DNA Repair Mechanism And Their Types pptx Biology Diagrams DNA errors occur during S phase; DNA repair mechanisms occur in G 2 phase before cells can proceed to M (mitosis). To progress from G 2 to M, cdc2 (red) activation needs to occur. Cdc2 becomes activated when coupled with its cofactor, cyclin B (green); then, the complex becomes phosphorylated at threonine 160 residue by the cdk7, also known as
Recruitment of CtIP to S phase DNA damage sites appears to be increased by its interaction with AUNIP, Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol. Cell, 47 (2012), pp. 320-329. 10.1016/j.molcel.2012.05.052. Recent studies have provided insights into the mechanisms that regulate DNA repair in specific cell-cycle phases and the pathways that ensure cell-cycle progression or arrest in normal and
How cells ensure correct repair of DNA double Biology Diagrams
However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine-tuning are known to destabilize cellular metabolic homeostasis, as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in
During the DNA-synthesis (S) phase of each cell-division cycle that is undertaken by any of the 10 13 -10 14 cells in our body, one of the miracles of life occurs โ the entire human genome
The DNA damage response during an unperturbed S Biology Diagrams
The choice between these pathways depends on cell-cycle phase; however the continuous effect of cell cycle on the balance between them is still unclear. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase Mol Cell. 2012 Jul 27;47(2):320-9. doi: 10.1016/j.molcel.2012.
