Dynamics of developmental neurogenesis and early cell survival A Biology Diagrams Once neurogenesis is complete, mature neurons do not divide. Herrup and Yang outline the evidence that, in order to achieve this, adult neurons must constantly hold their cell cycle in check, and
For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the mol โฆ
Cell cycle regulation, neurogenesis, and depression Biology Diagrams
The advances presented by Pechnick et al. broaden the focus to urge further elucidation of cell cycle and its regulators in adult neurogenesis. Because cell cycle regulators, including p21, also control proliferation and survival of brain tumor stem cells, attempts to consider such regulators as "druggable" therapeutic targets require a
The overall size of the brain is governed by cell cycle machinery. This is clearly demonstrated by the enlarged brains of mice lacking the rather ubiquitous cell cycle inhibitor p27Kip1 Fero et al. 1996, Nakayama et al. 1996.But as some parts of the brain tend to be larger than others, many cell cycle components are expressed in specific areas and control regional growth.
Neurogenesis and the Cell Cycle Biology Diagrams
Keywords: Cell cycle, Differentiation, Neurogenesis, Proneural, Central nervous system. Introduction. During development of the central nervous system (CNS), a period of extensive proliferation is needed to generate the required number of progenitor cells for correct tissue and organ formation. This must be accompanied or closely followed by
For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the molecular machinery of the cell cycle is used in the processes of size regulation in the brain